Therapeutic use of VR serious games in the treatment of negative schizophrenia symptoms : a systematic review

Schizophrenia is a chronic brain disorder that affects 1 in every 300 people worldwide. This study intended to perform a systematic review to describe the state-of-the-art of interventions involving patients with negative symptoms of schizophrenia that use Virtual Reality (VR) games as a complement to therapy, and to analyze the key features of such games. Literature research was conducted in three databases, namely, the Institute of Electrical and Electronics Engineers (IEEE), Scopus, and PubMed, to identify relevant publications dated from 2010 to 2021. Of the initial 74 publications found, only 11 satisfied the eligibility requirements and were included in this study. The results were then organized and displayed in a flow diagram. Overall, the results from the studies suggest that the use of VR in therapies enables an increase in social skills and a decrease in anxiety symptoms. The use of such technology in therapy has proven to be effective, although it still lacks features to provide better long-term results.2411-78B2-7CDB | Pedro Miguel MoreiraN/

Architecture for museums location-based content delivery using augmented reality and beacons

The digital transformation applied to museum's context is somehow usual nowadays, presenting many benefits to the visitors. However, most of the applications provide static and basic information that is not appealing nor promotes the involvement of the visitor in the tour. This paper proposes an architecture of a location-based content delivery inside a museum, based on a dynamic approach that promotes the visitor to immerse in the tour's story. The solution was created as a response to a real case study for the Foz C?a museum in Portugal. The proposed solution uses beacons, for the indoor location of visitors, and augmented reality for providing contents based on what the user is seeing, following a narrative that captures his attention at all times and providing artifact's details that the naked eye can not see. A comparative study was made to determine the properties and compare two augmented reality tools: Immersal AR and EasyAR. The precision of beacons detection, under different conditions and configurations, was also presented as preliminary results of this work.5311-8814-F0ED | Sara Maria da Cruz Maia de Oliveira PaivaN/

Testing the binary black hole paradigm through the Fe Kalpha line profile: application to 3C 273

We propose the study of long-term variations in the Fe Kalpha line profile as a discriminator for binary black hole (BH) systems. The existence of a binary BH in the center of an active galaxy will produce a particular signature in the evolution of the line profile, as a result of disk precession. This signature is a periodic variation of the position of the blue edge of the profile, accompanied by periodic change of its intensity. We show that detection of the former is clearly within the observational capabilities of planned X-ray missions. Detecting a periodic variation of line profiles would provide the first direct evidence for precessing discs in active galactic nuclei, as opposed to the existing evidence supporting only the precession of jets. We apply these ideas to 3C 273.Comment: Astrophysical Journal Letters, in press. 2 figures, 1 tabl

Probing the precession of the inner accretion disk in Cygnus X-1

We show that changes in the orientation of the inner accretion disk of Cygnus X-1 affect the shape of the broad Fe K$\alpha$ emission line emitted from this object, in such a way that eV-level spectral resolution observations (such as those that will be carried out by the {\it ASTRO-E2} satellite) can be used to analyze the dynamics of the disk. We here present a potential diagnostic tool, supported by numerical simulations, by which a few observations of Cygnus X-1, separated in time, can determine whether its accretion disk actually precesses, and if so, determine its period and precession angle. This approach could also be used for similar studies in other microquasar systems.Comment: To appear in The Astrophysics Journa

Deployment of a smart and predictive maintenance system in an industrial case study

Industrial manufacturing environments are often characterized as being stochastic, dynamic and chaotic, being crucial the implementation of proper maintenance strategies to ensure the production efficiency, since the machines? breakdown leads to a degradation of the system performance, causing the loss of productivity and business opportunities. In this context, the use of emergent ICT technologies, such as Internet of Things (IoT), machine learning and augmented reality, allows to develop smart and predictive maintenance systems, contributing for the reduction of unplanned machines? downtime by predicting possible failures and recovering faster when they occur. This paper describes the deployment of a smart and predictive maintenance system in an industrial case study, that considers IoT and machine learning technologies to support the online and real-time data collection and analysis for the earlier detection of machine failures, allowing the visualization, monitoring and schedule of maintenance interventions to mitigate the occurrence of such failures. The deployed system also integrates machine learning and augmented reality technologies to support the technicians during the execution of maintenance interventions.2411-78B2-7CDB | Pedro Miguel MoreiraN/

Using AR interfaces to support industrial maintenance procedures

Industries are becoming more and more digitized to better implement intelligent and predictive maintenance support systems, aligned with Industry 4.0, which requires the progressive digitization of data collection and processes. Maintenance interventions, in an evolving technological context, are increasingly more complex and difficult for technicians to perform. In these environments, the use of Augmented Reality (AR) to help assist and guide in the maintenance operations, can accomplish a considerable gain in productivity. AR allows to superimpose information objects in real scenes, such as text, images, audiovisuals, and 2D/3D model animations, making available contextual information about the process, based on location and perspective. This paper describes the design and implementation of a prototype augmented reality application to support maintenance tasks inside a metal stamping production unit, that produces components for the automotive sector. It aims to train and guide personnel during the maintenance operations, and offering an extra channel to reach expert help.2411-78B2-7CDB | Pedro Miguel MoreiraN/

High energy emission from microquasars

The microquasar phenomenon is associated with the production of jets by X-ray binaries and, as such, may be associated with the majority of such systems. In this chapter we briefly outline the associations, definite, probable, possible, and speculative, between such jets and X-ray, gamma-ray and particle emission.Comment: Contributing chapter to the book Cosmic Gamma-Ray Sources, K.S. Cheng and G.E. Romero (eds.), to be published by Kluwer Academic Publishers, Dordrecht, 2004. (19 pages

Particle Path Correlations in a Phonon Bath

The path integral formalism is applied to derive the full partition function of a generalized Su-Schrieffer-Heeger Hamiltonian describing a particle motion in a bath of oscillators. The electronic correlations are computed versus temperature for some choices of oscillators energies. We study the perturbing effect of a time averaged particle path on the phonon subsystem deriving the relevant temperature dependent cumulant corrections to the harmonic partition function and free energy. The method has been applied to compute the total heat capacity up to room temeperature: a low temperature upturn in the heat capacity over temperature ratio points to a glassy like behavior ascribable to a time dependent electronic hopping with variable range in the linear chain.Comment: To be published in J.Phys.:Condensed Matte

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis

Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (IrIII) complexes [Ir(Cpx)(XY)Cl]+/0 (Cpx = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cpx ring. In comparison, highly potent complex 4 (Cpx = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these IrIII complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 μM) of the γ-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic IrIII complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands